Ketamine therapy that earns its place in real medicine.
We're opening a physician-led ketamine & Spravato clinic in East Islip in Fall 2026. Not an app that mails you medicine — a real treatment program with at-home ketamine, in-clinic IV infusions, and FDA-approved Spravato, held together by one careful pathway. Join the waitlist to be among the first patients seen.
The Pathway
01 — 03In-person evaluation
A real diagnostic visit before any medicine is prescribed.
Supervised induction
First doses observed and calibrated in clinic.
At-home maintenance
Continued care at home with monitoring & oversight.
Three evidence-based options, one standard of care
Every patient begins with a thorough evaluation. From there, your physician recommends the route that fits your history and your safety.
At-Home Ketamine
Sublingual ketamine maintenance taken at home — only after an in-person evaluation and supervised in-clinic dosing. The convenience of home, the structure of a clinic.
- Trained peer monitor every session
- Dose calibrated, never guessed
- Virtual check-ins & messaging
IV Ketamine
In-clinic intravenous infusions in a calm, monitored setting. Precise dosing, continuous vitals, and a clinician present from the first drop to discharge.
- Continuous BP monitoring
- Comfortable private recovery
- Physician oversight each visit
Spravato®
The first FDA-approved esketamine nasal spray for treatment-resistant depression — available as monotherapy or alongside an oral antidepressant, administered in clinic under REMS.
- REMS-certified site
- 2-hour monitored observation
- Insurance & prior authorization
Why it's called a pathway
A trellis is the structure a plant climbs as it grows. Your treatment works the same way — the medicine helps your brain rebuild; the pathway keeps that growth steady and safe.
Comprehensive Evaluation
You meet your physician in person for a full diagnostic visit. We confirm this is the right treatment before any medicine is prescribed.
- Psychiatric & medical history
- Suitability & safety screening
- A plan built around you
Supervised Induction
Your first doses happen in clinic, observed and monitored. We learn how you respond and calibrate the dose that's right for you.
- Clinician-observed dosing
- Vital monitoring throughout
- Dose calibrated to response
At-Home Maintenance
Once you're stable, treatment continues in the comfort of home — with a trained peer monitor, virtual check-ins, and your physician on call.
- Peer-monitored home sessions
- Virtual visits & messaging
- 90-day re-evaluation
Clinic-grade care, without the friction
Trellis Pathway runs on purpose-built software, so the parts that usually make treatment a hassle simply work.
Virtual visits
Secure video and a virtual waiting room — no commute for routine check-ins.
Effortless check-in
Paperwork handled before you arrive. Walk in and you're ready.
One-tap payment
Transparent pricing and saved one-tap pay — no card fumbling each visit.
Always reachable
Message your care team between visits. On-call coverage 24/7.
A program, not a prescription pad
Most at-home ketamine arrives in the mail with little more than a video call. We do it differently.
- Pill ships after a 15-minute video form
- No in-person physician relationship
- Dose set once, rarely adjusted
- No monitoring, no peer support
- Full diagnostic evaluation in person, every time
- Supervised induction before any home dosing
- Dose calibrated and re-evaluated at 90 days
- Vetted peer monitor for every home session
The software behind this clinic.
Trellis Pathway runs on Trellis — the same clinical platform we use to operate this Spravato® and ketamine program end-to-end: referrals, screening, supervised induction, REMS-aligned monitoring, and long-term maintenance. If you're a clinician building a program of your own, you can run it on the same rails.
See Trellis for providersWhat patients
ask first
Spravato® (esketamine) is FDA-approved for treatment-resistant depression and is what we run on a buy & bill basis through Medicare and most commercial plans. Generic IV and at-home sublingual ketamine are used off-label, under the same physician oversight.
Only after an in-person evaluation and a supervised induction in clinic. Once you're stable on dose, maintenance sessions are done at home with a vetted peer monitor present and a clinician on call.
Spravato® is typically billed to insurance and we handle prior authorization end-to-end. Medicare Part B covers Spravato administration on a buy & bill basis. IV and at-home ketamine programs are flat-rate cash pay.
Most patients we see have tried at least one or two antidepressants without full relief. Your evaluation covers diagnosis, medical history, and risk — we'll tell you honestly whether a Trellis Pathway program is the right fit, and what we'd recommend if it isn't.
Send a referral through our provider page. We confirm receipt within one business day, schedule the evaluation, and loop you in on diagnosis, treatment plan, and progress notes throughout the patient's program.
Real relief begins with
one honest conversation.
Become a patient and our care team will reach out to schedule your evaluation. No commitment — just a conversation.